PARAINFLUENZA VIRUS GLYCOPROTEINS AND VACCINES

摘要

The hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins are coisolated and copurified from the parainfluenza virus type 1 (PIV-1) and parainfluenza virus type 3 (PIV-3). The HN and F glycoprotein are separately isolated and purified from parainfluenza virus type 2 (PIV-2). The glycoproteins formulated as vaccines, are highly immunogenic and protect relevant animal models against parainfluenza challenge. A vaccine containing the HN and F glycoproteins from PIV-3 was safe and immunogenic in adults and children. A trivalent vaccine containing HN and F glycoproteins from PIV-1, PIV-2 and PIV-3 generated an immune response capable of neutralizing each of the viruses.