| 发明名称 |
FUSION PROTEINS FOR PRODRUG-ACTIVATION |
| 摘要 |
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain. |
| 申请公布号 |
EP0590530(A3) |
申请公布日期 |
1997.03.26 |
| 申请号 |
EP19930115418 |
申请日期 |
1993.09.24 |
| 申请人 |
BEHRINGWERKE AKTIENGESELLSCHAFT |
发明人 |
GEHRMANN, MATHIAS;SEEMANN, GERHARD;BOSSLET, KLAUS;CZECH, JOERG |
| 分类号 |
A01K67/027;A61K38/00;A61P35/00;C07K14/00;C07K14/705;C07K16/00;C07K16/18;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N9/24;C12N15/09;C12N15/62;C12N15/81;C12P21/02;C12R1/865;G01N33/53;G01N33/68;(IPC1-7):C12N15/62;C07K15/28;A61K37/02 |
主分类号 |
A01K67/027 |
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