发明名称 |
Controlled release preparation |
摘要 |
An oral controlled release pharmaceutical preparation in the form of a tablet, capsule or sachet containing a plurality of coated particles comprising a therapeutically effective amount of a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine in that the serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after administration of a single dose, and providing a significantly reduced plasma concentration fluctuation compared to known morphine preparations. A method for the manufacture of such a preparation and the use of such preparations for the manufacture of an analgesic useful in the treatment of severe chronicle pain are also provided.
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申请公布号 |
US5614218(A) |
申请公布日期 |
1997.03.25 |
申请号 |
US19940213518 |
申请日期 |
1994.03.16 |
申请人 |
PHARMACIA & UPJOHN AKTIEBOLAG |
发明人 |
OLSSON, BIRGITTA;PESONEN, MARITTA A.;RAGNARSSON, GERT |
分类号 |
A61K9/22;A61K9/48;A61K9/50;A61K9/62;A61K31/485;A61K47/38;A61P25/04;(IPC1-7):A61K9/48 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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