| 摘要 |
PCT No. PCT/GB94/02557 Sec. 371 Date May 20, 1996 Sec. 102(e) Date May 20, 1996 PCT Filed Nov. 21, 1994 PCT Pub. No. WO95/14690 PCT Pub. Date Jun. 1, 1995A class of substituted morpholine derivatives of formula <IMAGE> (I) wherein Y represents an optionally substituted bicyclic heteroaromatic ring system containing one or two nitrogen atoms, the ring system comprising a six-membered aromatic or heteroaromatic ring fused to a five- or six-membered heteroaromatic ring; and Z represents an optionally substituted arylalkyl, aryloxymethyl or arylalkoxymethyl group, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia.
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