发明名称 |
Peptide, production and use thereof |
摘要 |
A peptide represented by the formula: <IMAGE> [I] <IMAGE> wherein R1 represents an oil-soluble group; R2 and R5 represent a hydrogen atom or a lower alkyl group; R3 represents an aliphatic group which may have O or S; R4 represents a heterocyclic-substituted lower alkyl group; R6 represents a hydrogen atom, a lower alkyl group or an aromatic cyclic group; X represents a group having an aromatic ring; n represents an integer of 0 or more and m represents an integer of 2 or more, or a salt thereof exhibits a marked endothelin receptor-antagonistic action, and the peptide [I] is pharmaceutically useful as a therapeutic agent for hypertension, cardiovascular disease and renal disease, for instance.
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申请公布号 |
US5614497(A) |
申请公布日期 |
1997.03.25 |
申请号 |
US19920992131 |
申请日期 |
1992.12.17 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
KITADA, CHIEKO;OHTAKI, TETSUYA;FUJINO, MASAHIKO |
分类号 |
A61K38/00;C07K5/02;C07K7/02;C07K14/575;(IPC1-7):A61K38/00;C07K5/10;C07K7/00;C07K7/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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