Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions

摘要

Quaternary amine-containing ether lipid analogs of the formulaR1-X-R2-N+(R3) (R4) (R5) Z-are disclosed. R1 represents a hydrophobic group and R2 represents the backbone of the molecule, with the quaternary amine being linked directly to the backbone. Pharmaceutical compositions including these compounds and methods of combating tumors with these compounds are disclosed. Also disclosed is a method of combating viral infections with both these compounds and ET-18-OMe and its analogs.