HYDROLYSIS-PROMOTING TAXANE HYDROPHOBIC DERIVATIVES

摘要

Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysispromoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarly occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers.