A process for improving the treatment of a tumor by radiation therapy which comprises treating a tumor by radiation therapy wherein the cells of the tumor have been transduced with a polynucleotide encoding wild-type p53, such as, for example, by transducing the tumor cells with an adenoviral vector including a DNA sequence encoding wild-type p53. Such a combination treatment of the transduction of tumor cells with a polynucleotide encoding wild-type p53 and radiation therapy provides a more effective treatment than by using p53 gene therapy alone or radiation therapy alone.
申请公布号
WO9710007(A1)
申请公布日期
1997.03.20
申请号
WO1996US15342
申请日期
1996.09.13
申请人
GENETIC THERAPY, INC.;STANFORD UNIVERSITY;CHIANG, YAWEN, L.;CHANG, ESTHER, H.