Methods of cleavage of a polymer of deoxyribonucleic acid using photosensitive texaphyrins are disclosed. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.
申请公布号
FI971176(A0)
申请公布日期
1997.03.20
申请号
FI19970001176
申请日期
1997.03.20
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;PHARMACYCLICS, INC.
发明人
MAGDA, DARREN;SESSLER, JONATHAN L.;IVERSON, BRENT L.;SANSOM, PETRA I.;WRIGHT, MEREDITH;MODY, TARAK D.;HEMMI, GREGORY W.