发明名称 |
OLIGOMERS WHICH INHIBIT EXPRESSION OF COLLAGEN GENES |
摘要 |
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian alpha 1(I) collagen gene.
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申请公布号 |
WO9710254(A1) |
申请公布日期 |
1997.03.20 |
申请号 |
WO1996US14640 |
申请日期 |
1996.09.12 |
申请人 |
GUNTAKA, RAMAREDDY, V. |
发明人 |
GUNTAKA, RAMAREDDY, V.;WEBER, KARL, THEODORE;KOVACS, ATTILLA;KANDALA, JAGANNADHACHARI |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K38/00;A61K48/00;A61P1/00;A61P1/16;A61P9/00;A61P9/10;A61P11/00;A61P17/00;A61P17/02;C12N15/113;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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