发明名称 |
USE OF CYCLODEXTRINS TO MODULATE GENE EXPRESSION WITH REDUCED IMMUNOSTIMULATORY RESPONSE |
摘要 |
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by administering the phosphorotioate oligonucleotide in a therapeutic formulation which includes at least one cyclodextrin to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention. |
申请公布号 |
WO9710005(A2) |
申请公布日期 |
1997.03.20 |
申请号 |
WO1996US13311 |
申请日期 |
1996.08.19 |
申请人 |
HYBRIDON, INC. |
发明人 |
ZHAO, QIUYAN;TEMSAMANI, JAMAL;AGRAWAL, SUDHIR |
分类号 |
A61K47/40;A61K31/00;A61K47/48;A61K48/00;A61P37/00;A61P37/06;(IPC1-7):A61K47/48;A61K49/00 |
主分类号 |
A61K47/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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