发明名称 |
Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide |
摘要 |
Methods are disclosed for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme and a facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme and an effective amount of a facilitator oligonucleotide.
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申请公布号 |
US5612469(A) |
申请公布日期 |
1997.03.18 |
申请号 |
US19950431625 |
申请日期 |
1995.05.01 |
申请人 |
WORCESTER FOUNDATION FOR EXPERIMENTAL BIOLOGY |
发明人 |
GOODCHILD, JOHN |
分类号 |
A61K38/00;C07K14/16;C12N15/113;(IPC1-7):C12N15/11;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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