发明名称 |
SCREEN FOR COMPOUNDS WITH AFFINITY FOR RNA |
摘要 |
The present invention provides methods for high-throughput screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve measuring the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA conformation.
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申请公布号 |
WO9709342(A1) |
申请公布日期 |
1997.03.13 |
申请号 |
WO1996US14729 |
申请日期 |
1996.09.06 |
申请人 |
SCRIPTGEN PHARMACEUTICALS, INC. |
发明人 |
ARENAS, JAIME, E.;LILLIE, JAMES, W.;PAKULA, ANDREW, A. |
分类号 |
G01N33/566;C12N15/09;C12Q1/68;(IPC1-7):C07H21/02;C07H21/04;G01N33/48 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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