| 摘要 |
<p>Isothiourea derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R?1, R2 and R3¿ independently represent each hydrogen, halogeno, nitro, lower alkyl or lower alkoxy; R?4 and R5¿ independently represent each hydrogen, lower alkyl or substituted alkyl, or R?4 and R5¿ together form -(CH¿2?)n-; Z represents -(CH2)m- or CH2O(CH2)2-; n is 2 or 3; and m is 1, 2 or 3. The compounds (I) of pharmacologically acceptable salts thereof have an excellent function of inhibiting the Na?+/Ca2+¿ exchange mechanism.</p> |
