NOVEL ISOTHIOUREA DERIVATIVES

摘要

Isothiourea derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R<1>, R<2> and R<3> independently represent each hydrogen, halogeno, nitro, lower alkyl or lower alkoxy; R<4> and R<5> independently represent each hydrogen, lower alkyl or substituted alkyl, or R<4> and R<5> together form -(CH2)n-; Z represents -(CH2)m- or CH2O(CH2)2-; n is 2 or 3; and m is 1, 2 or 3. The compounds (I) of pharmacologically acceptable salts thereof have an excellent function of inhibiting the Na<+>/Ca<2+> exchange mechanism.