发明名称 |
METHOD FOR THE PRODUCTION OF MAGNESIUM PYRIDOXAL-5'-PHOSPHATE GLUTAMATE AND INTERMEDIATE PRODUCTS OBTAINED THEREBY |
摘要 |
The invention relates to a method for the production of magnesium pyridoxal-5'-phosphate glutamate, in which pyridoxine or an acid addition salt thereof is oxidised with manganese (IV) oxide to pyridoxal; pyridoxal is reacted with p-phenetidine under formation of the Schiff's base p-phenetidyl-pyridoxal; p-phenedityl-pyridoxal is selectively phosphorylated on the 5'-hydroxymethyl group under formation of p-phenetidyl-pyridoxal-5'-phosphate; p-phenetidyl-pyridoxal-5'-phosphate is hydrolysed under formation of an alkali metal salt of pyridoxal-5'-phosphate; the alkali metal ions are removed in order to obtain pyridoxal-5'-phosphate; pyridoxal-5'-phosphate is reacted with a reaction product of a magnesium alcoholate and L-glutamic acid; and the formed magnesium pyridoxal-5'-phosphate glutamate is isolated. Furthermore, the invention relates to intermediate products obtained with this method. |
申请公布号 |
WO9709334(A1) |
申请公布日期 |
1997.03.13 |
申请号 |
WO1996EP03749 |
申请日期 |
1996.08.26 |
申请人 |
STEIGERWALD ARZNEIMITTELWERK GMBH;MAIDONIS, PANAGIOTIS;SCHNEIDER, WERNER |
发明人 |
MAIDONIS, PANAGIOTIS;SCHNEIDER, WERNER |
分类号 |
C07D213/66;C07F9/58 |
主分类号 |
C07D213/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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