CEPHALOSPORIN DERIVATIVES

摘要

The present invention relates to cephalosporin derivatives of the general formula I <IMG> wherein R1 is a group selected from 2-, 3- and 4-hydroxyphenyl, 2- and 3 methoxyphenyl, 4-carboxyphenyl, 4-carbamoylphenyl, 3-trifluoro-methylphenyl, 2- and 3-fluorophenyl, 3-nitrophenyl, 3-fluoro-4-hyroxyphenyl, 2-fluoro-4-hydroxyphenyl, 3-fluoro-2-hydroxy-phenyl, 3-, 4-dihydroxyhenyl, benzyl, -CHR-phenyl, 3-hydroxy-benzyl, 4-aminobenzyl, 2-, 3- and 4-fluorobenzyl, 2-, 3- and 4methoxybenzyl, 4-nitrobenzyl, 4-carboxybenzyl, 4-trifluoromethyl-benzyl, 1-naphthyl and 2-naphthyl, all hydroxy, amino, carboxy and carbamoyl substituents optionally being substituted, or is pyridinyl mono-substituted with halogen, pyrimidyl, pyrazinyl di-substituted with lower alkyl, pyridazinyl mono-substituted with halogen, piperidinyl in which the amino group may be substituted by an acyl group, thiadiazolyl, oxo-tetrahydrofuranyl, thiophenyl monosubstituted with lower alkoxycarbonyl or carbamoyl, tetrazolyllower alkyl, tetrahydrofuranyl-lower alkyl, thiophenyl-lower alkyl or benzimidazolyl-lower alkyl; and R is carboxy or esterified carboxy; readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts, as well as the their use and the process for manufacturing such compounds.