10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3,8]undec-2-ene-2-carboxylic acid derivatives

摘要

Compounds of the general formula (I) in which:- R1 represents a hydroxyl protecting group; and R2 represents a hydrogen or halogen atom, an azido group, a C1-3 alkyl group, a group (CH2)mOR3 wherein m is zero or one and R3 represents a hydrogen atom or a hydroxyl protecting group, an azidoethoxy group, a protected hydroxyethoxy group or a group XR4 in which X is an oxygen atom or the group S(O)n in which n is zero, 1 or 2 and R4 represents a C1-5alkyl, C3-7 cycloalkyl or phenyl group or when X is oxygen or sulphur then R4 may also represent the group AlkNR5R6 in which Alk represents a C2-6 straight or branched alkylene chain and R5 and R6 independently represent a hydrogen atom or C1-4alkyl group or R5 and R6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring or the group NR5R6 represents a protected amino group, or R2 represents the group (CH2)mNR7R8 in which m is zero or 1 and R7 and R8 independently represent a hydrogen atom or a C1-4alkyl group or NR7R8 represents a protected amino group, or R2 and the carbon atom to which it is attached represent a keto group or a ketal derivative thereof; and acid addition salts of such compounds containing basic centres.