发明名称 |
Methods of assessing mhc class i expression and proteins capable of modulating class i expression |
摘要 |
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules. In addition, this invention relates to nucleic acid and amino acid sequences for proteins capable of modulating MHC Class I expression. |
申请公布号 |
AU6860096(A) |
申请公布日期 |
1997.03.12 |
申请号 |
AU19960068600 |
申请日期 |
1996.08.21 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED B |
发明人 |
LEONARD KOHN;DINAH S SINGER;MOTOYASU SAJI;CESIDIO GIULIANI;MINHO SHONG;KOICHI SUZUKI;MASAYUKI OHMORI |
分类号 |
C12N15/09;A61K31/00;A61K48/00;A61P37/00;A61P37/06;C07K14/47;C07K14/74;C07K16/18;C12N15/00;C12P21/02;C12P21/08;C12Q1/26;C12Q1/68;C12R1/91;G01N33/15;G01N33/53;G01N33/566;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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