Non-classical antifolates

摘要

2-Amino-4-hydroxy-4,5,6,7-tetrahydropyridoÄ2,3-dÜpyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-ä4-Ä2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyridoÄ2,3-dÜpyrimidin -6-yl)ethylÜbenzoylü-L- gamma -glutamyl)-D-aspartic acid.