| 摘要 |
This invention provides the synthetic method of M-L-aspartyl-L-phenyl alanine-methyl ester. M-L-aspartyl-L-phenyl alanine-methyl ester chlorinate salt is neutralized to yield mother solution containing M-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-diketo piperazine. Said solution is condensed by vacuum condensation, added methanol containing 0.1 to 14 parts by weight of strong acid and stirred for 0.5 to 6 hours at 0 to 70 degree Celsius. Then DKP is converted bo M-APM and M-L-aspartyl-L-phenylalanine methyl ester.
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