发明名称 Methods of preparing manganese complexes of nitrogen-containing macrocyclic ligands
摘要 The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: <IMAGE> wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.
申请公布号 US5610293(A) 申请公布日期 1997.03.11
申请号 US19950442455 申请日期 1995.05.16
申请人 MONSANTO COMPANY 发明人 RILEY, DENNIS P.;WEISS, RANDY H.;NEUMAN, WILLIAM L.;MODAK, ANIL S.;LENNON, PATRICK J.;ASTON, KARL W.
分类号 A61K31/555;C07D259/00;C07F13/00;(IPC1-7):C07D259/00;C07D257/00 主分类号 A61K31/555
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