| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel bisisoflavone as a 5α-reductase inhibitor which has the inhibitory action against 5α-reductase and is useful as a preventive and therapeutic agent for prostatic hyperplasia. SOLUTION: A-758491 of the formula or its salt. The compound of the formula has the following physical and chemical properties: properties: pale yellow powder; molecular formula: C30 H18 O10 (determined by high-resolution mass spectroscopy); molecular weight: 538 (mass spectrometry); solubility: soluble in methanol, ethanol, acetone, dimethyl sulfoxide and benzene, insoluble in water, chloroform, diethyl ether, ethyl acetate; color reaction: positive to sulfuric acid and iodine. The compound of the formula is obtained by aerobically culturing SANK 60695 strain.
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