| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject compound having a high optical purity by using an inexpensive and industrially available boron metal hydride as a hydrogen source. SOLUTION: This optically active alcohol is obtained by effecting (B) (i) asymmetric ketones of the formula R<6> -CO-R<7> [R<6> , R<7> are each a different (substituted) alkyl, a (substituted) aryl, etc.] and (ii) and acid such as a Broensted acid, a lewis acid, etc., to the mixture of (A) (i) an optically activeβ-amino alcohol of the formula [R<1> is H, a lower alkyl or a (substituted) aralkyl; R<2> to R<5> are each H, a lower alkyl, a (substituted) aryl, a (substituted) aralkyl, etc.] and (ii) a borane compound obtained from a boron hydride or a boron metal hydride and an acid. Further, the optically activeβ-amino alcohol is used by 0.01-0.5 molar times (preferably by 0.02-0.4 molar times) the asymmetric ketones. |
