2,3-disubstituted isoxazolidines, a process for their preparation, agents containing them, and their use

摘要

The invention relates to compounds of the formula <IMAGE> (I) in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A1 represents CO, CS, C=NH, CN-alkyl, CN-O-alkyl, SO, optionally substituted CH2 or a bond; A2 represents NH, NCH3, O, CH2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C=NH; A3 represents O, NH, NCH3 or a bond; R4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.