| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound extracted from a tropical plant, Aglaia odorata, having a cancer gene function-depressing activity, and useful as an active ingredient for anticancer drugs. SOLUTION: A compound of the formula, aglaiastatin A. The compound of the formula is obtained by drying Aglaia odorata, a small tree of the Meliaceae, naturally growing in the Southern East Asia, preferably with sunlight, etc., grinding the dried plant, extracting the ground plant preferably with a non-polar solvent, especially preferably a hydrocarbon solvent or a halogenated hydrocarbon solvent, and subsequently isolating and purifying the extract preferably with column chromatography, high performance liquid chromatography, thin layered chromatography, etc. The compound of the formula has the following characteristics; molecular weight: 434, colorless powder, Rf value in silica gel thin layer chromatography: 0.58 (developing solven:chloroform:methanol = 40:1), 0.58 (developing solvent:toluene:acetone = 2:1), and melting point : 68-71 deg.C. |
