Esters of thienyl carboxylic acids and amino alcohols and their quaternization products

摘要

Compounds of the formula <IMAGE> of which, in exemplary compounds, the thienyl group is attached via the 2-position and: (a) A is 3 alpha -(6 beta , 7 beta -epoxy)-tropanyl methobromide and R1 is 2-thienyl; (b) A is 3 alpha -(6, 7dehydro)-tropanyl methobromide and R1 is 2-thienyl; (c) A is 3 beta -tropanyl methobromide and R1 is 2-thienyl; and, (d) A is 3 alpha -(N-isopropyl)-nortropanyl methobromide and R1 is cyclopentyl. These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.