Package form for bicarbonate-containing powdery pharmaceutical compositions and a method of stabilizing the compositions

摘要

PCT No. PCT/JP94/00041 Sec. 371 Date Mar. 14, 1995 Sec. 102(e) Date Mar. 14, 1995 PCT Filed Jan. 14, 1994 PCT Pub. No. WO94/16663 PCT Pub. Date Aug. 4, 1994The invention provides a method and a package form for insuring a stabilized bicarbonate-containing pharmaceutical composition, the method comprises filling the bicarbonate-containing powdery pharmaceutical composition in a moisture- and gas-permeable plastic container, wrapping the so-filled container in a moisture- and gas-impermeable plastic wrapper and carrying out at least one procedure selected from the group consisting of the procedure of introducing a carbon dioxide gas into a space between the container and wrapper, the procedure of disposing a carbon dioxide-liberating deoxygenating agent in the space and the procedure of disposing a desiccant previously saturated with carbon dioxide gas by way of adsorption in the space. In accordance with the invention, the inherent objects of incorporating the bicarbonate can be accomplished without inducing the aging and degradation of the bicarbonate-containing powdery pharmaceutical composition.