| 摘要 |
The invention concerns a novel method of producing dihydroxypyrimidine derivatives of general formula (I), in which R1 and R2 are identical or different and designate a hydrogen atom, a C1 - C4 alkyl group or an aryl group. In the first step, as a substrate, a compound of general formula (II), in which R2 has the above meaning and R3 designates -CN or COOR4, R4 being a C1 - C4 alkyl group, is converted by microorganisms of the Rhodococcus species into a malonic acid derivative of general formula (III), in which R2 has the above meaning and R5 designates a C1 - C4 alkoxy group or -NH2, and this derivative is then cyclized in the second step with a carboxylic acid amide of general formula (IV), in which R1 has the above meaning, in the presence of a base to form an end product according to formula (I).
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