METHOD AND DEVICE FOR INVESTIGATING NON-LINEAR OPTICAL BEHAVIOR OF A LAYER FORMED FROM FIRST AND SECOND REACTANTS E.G. ANTIBODY AND ANTIGEN
摘要
A method and a device for optically ascertaining the mutual binding of a first and a second reactant are described. Use is made of the fact that a dipolar layer (7) having a non-linear optical behavior is formed upon a reaction between the two reactants. The formation of such a layer is ascertained by illuminating the substance with radiation (8) having one or two frequencies, and by detecting whether radiation (10) from the substance contains a component at a frequency which is twice the frequency, or a mixed term of the frequency of the radiation incident on the substance.
申请公布号
WO9708554(A1)
申请公布日期
1997.03.06
申请号
WO1996IB00806
申请日期
1996.08.16
申请人
PHILIPS ELECTRONICS N.V.;PHILIPS NORDEN AB;HOLLERING, ROBERTUS, WILHELMUS, JACOBUS;BARMENTLO, MAARTEN