METHOD OF PRODUCING DIHYDROXYPYRIMIDINE DERIVATIVES

摘要

The invention concerns a novel method of producing dihydroxypyrimidine derivatives of general formula (I), in which R<1> and R<2> are identical or different and designate a hydrogen atom, a C1 - C4 alkyl group or an aryl group. In the first step, as a substrate, a compound of general formula (II), in which R<2> has the above meaning and R<3> designates -CN or COOR<4>, R<4> being a C1 - C4 alkyl group, is converted by microorganisms of the Rhodococcus species into a malonic acid derivative of general formula (III), in which R<2> has the above meaning and R<5> designates a C1 - C4 alkoxy group or -NH2, and this derivative is then cyclized in the second step with a carboxylic acid amide of general formula (IV), in which R<1> has the above meaning, in the presence of a base to form an end product according to formula (I).