PHARMACEUTICAL COMPOSITIONS FOR THE NASAL DELIVERY OF COMPOUNDS USEFUL FOR THE TREATMENT OF OSTEOPOROSIS

摘要

A pharmaceutical composition for the nasal delivery of compounds useful for treating osteoporosis, comprising an effective amount of a physiologically active truncated analog of PTH or PTHrp, or salt thereof, in which amino acid residues (22-31) form an amphipathic alpha -helix, said residues (22-31) selected from (SEQ ID NOS: 85, 86, 26, 27, 28, 29, and 30); an absorption enhancer selected from the group consisting of dimethyl- beta -cyclodextrin and the bile acid surfactants; and water is provided.