PROCESS FOR THE MANUFACTURE OF PREFILLED SYRINGES

摘要

This invention relates to a process for manufacturing prefilled syringes where at least one of the syringe components is manufactured in at least a class 100 environment. The process includes the steps of manufacturing syringe components, such as the barrel and plunger substrate, within at least a class 100 and MCB-3 environment (210-218, 242-250); manufacturing syringe components, such as the plunger cover and tip seal in an environment less clean than a class 100 environment (252-262, 222-232); decontaminating the plunger cover and tip seal (264-265, 234-236); lubricating at least one of the barrel, plunger substrate, plunger cover and tip seal (220, 266, 238); assembling the barrel and tip seal to form a barrel/tip seal combination (240); assembling the plunger cover and plunger substrate to form a plunger (268); filling the barrel/tip seal combination with a predetermined amount of fluid (276); and final assembling of the prefilled syringe by inserting the plunger into the barrel/tip seal combination (278). When the syringe components are manufactured at different locations, each component is tripled-bagged to maintain the component substantially free from contaminants, and transported to an assembly site where the components are unpackaged and assembled into the barrel/tip seal combination and plunger. When filling and final assembly of the barrel/tip seal combination takes place at a location separate from its assembly site, the barrel/tip seal combination is tripled-bagged to maintain it substantially free from contaminants, and transported to a filling and final assembling site for filling and final assembling into a prefilled syringe.