发明名称 Methods for technetium/rhenium labelling of proteins
摘要 <p>A method for radiolabeling a protein with a radioisotope of technetium or rhenium comprises the steps of contacting a solution of a protein containing a plurality of adjacent free sulfhydryl groups, or in particular cases, intact protein containing at least one disulfide group, with stannous ions, and then with radiopertechnetate or radioperrhenate, the amount of stannous ion being sufficient to substantially completely reduce the radiopertechnetate or radioperrhenate, and recovering radiolabeled protein.</p>
申请公布号 EP0403225(B1) 申请公布日期 1997.03.05
申请号 EP19900306385 申请日期 1990.06.12
申请人 IMMUNOMEDICS, INC. 发明人 GRIFFITHS, GARY L.
分类号 A61K39/395;A61K51/00;A61K51/10;A61P31/00;A61P35/00;C07B59/00;C07K1/13;C07K16/00;(IPC1-7):C07K1/13;G01N33/534;A61K51/08 主分类号 A61K39/395
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