| 摘要 |
There is described the use of prostane derivatives of general formulae (I and Ia), wherein X1 is a -CH2-CH2, trans-CH=CH- or -CC- group, X2 is a linear or branched saturated hydrocarbon chain having from 1 to 6 carbon atoms, X3 is an -O- or -CH2- group, X4 is a -CH2- or -(CH2)3- group, X5 is a hydrogen atom or a -CC-R2 group, R1 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms or a phenyl group, R2 is a linear or branched, saturated or unsaturated hydrocarbon chain having from 1 to 6 carbon atoms, R3 is a hydrogen atom, an acyl radical having from 1 to 4 carbon atoms or a benzyl radical, and R4 is a hydrogen atom or a methyl group; the -O-R3- group being in the .alpha.- or .beta.-configuration, and their salts with physiologically tolerable bases when R1 represents a hydrogen atom, in the optional adjuvant treatment of bacterially induced meningitis, and also the combination of prostane derivatives with antibiotics.
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