METHOD OF PEPTIDE SYNTHESIS

摘要

FIELD: biochemistry, peptide chemistry. SUBSTANCE: invention describes synthesis of compound of the formula: A-Tyr-Pro-Ser-NH-B where: A - H-Tyr or X - Tyr-Y-Phe-Z where: X - H or optically active basic amino acid; Y - D-amino acid; Z - optically active amino acid; B - H or alkyl group. Synthesis is carried out in solution. Firstly, condensation of fragment Boc-Ser(Bzl)-NH-B is carried out in the presence of N-methylmorpholine and liquid chromatography is carried out on Diasorb-130 in acetonitrile solution. Preparations based on the synthesized peptide show antialcoholic action and can be used in complex with other peptide preparations and can be used in medicine as biologically active compounds. EFFECT: improved method of peptide synthesis.