ACYLATED OLIGOPEPTIDES CONTAINING PHOSPHOTYROSINE AS INHIBITORS OF PROTEIN TYROSINE KINASES

摘要

The invention relates to a compound of formula (I), wherein m is 2 to 15, X is arylcarbonyl, arylsulfonyl, cycloalkylcarbonyl, cycloalkanesulfonyl, heterocyclylcarbonyl or heterocyclylsulfonyl; A is absent or the bivalent radical of a natural or unnatural amino acid, B is the bivalent radical of a natural amino acid, PTI is the bivalent radical of phosphotyrosine or a phosphotyrosine mimic, AA stands for a bivalent radical of a natural or unnatural amino acid, and Y is hydroxy, a C-terminal protecting group or a primary, secondary or tertiary amino group, with the proviso that two or more sulfhydryl groups belonging to any amino acid A, B or AA are present as such or may form intramolecular disulfide bonds, or a salt thereof, said compound being useful for the treatment of diseases that respond to inhibition of the interaction of (a) protein(s) comprising (an) SH2 domain(s) and a protein tyrosine kinase or a modified version thereof.