摘要 |
<p>A process for preparing a solid dispersion of a hardly soluble medicine which comprises heating the hardly soluble medicine, an amorphism-inducing agent and an amorphism stabilizer or mechanochemically treating the same; and a process for producing a solid dispersion of a hardly soluble medicine which comprises high-frequency heating the hardly soluble medicine and an amorphism stabilizer. These processes make it possible to make hardly soluble medicines amorphous at a temperature lower than those employed in the conventional methods. The solid dispersions of the amorphous hardly soluble medicines thus obtained have an improved mucosal or rectal adsorption rate, which makes it possible to elevate their bioavailability.</p> |