METHOD FOR TREATMENT OF CANCER AND INFECTIOUS DISEASES AND COMPOSITIONS USEFUL IN SAME
摘要
Administration of expressible polynucleotides encoding eukaryotic heat shock proteins to mammalian cells leads to the stimulation of an immune response to antigens present in those cells. This makes it possible to stimulate an immune response to target antigens, including target tumor antigens or antigens associated with an infectious disease, without having to isolate a unique antigen or antigen-associated heat shock protein for each target antigen by administering to a mammalian subject or to a group of mammalian cells containing the antigen, an expressible polynucleotide encoding a heat shock protein. The expressed heat shock protein may have the same structure as native heat shock proteins, or may be a modified form adapted to control the trafficking of the expressed heat shock protein within the cells.
申请公布号
WO9706828(A1)
申请公布日期
1997.02.27
申请号
WO1996US13360
申请日期
1996.08.16
申请人
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;ROTHMAN, JAMES, E.;HARTL, F., ULRICH;HOE, MEE, H.;HOUGHTON, ALAN;TAKEUCHI, YOSHIZUMI;MAYHEW, MARK
发明人
ROTHMAN, JAMES, E.;HARTL, F., ULRICH;HOE, MEE, H.;HOUGHTON, ALAN;TAKEUCHI, YOSHIZUMI;MAYHEW, MARK