发明名称 |
METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF alpha v beta 5 MEDIATED ANGIOGENESIS |
摘要 |
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin alpha v beta 5 antagonists. The alpha v beta 5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor- alpha and epidermal growth factor. Inhibition of alpha v beta 5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing alpha v beta 5 antagonists.
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申请公布号 |
WO9706791(A1) |
申请公布日期 |
1997.02.27 |
申请号 |
WO1996US13194 |
申请日期 |
1996.08.13 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;BROOKS, PETER;CHERESH, DAVID, A.;FRIEDLANDER, MARTIN |
发明人 |
BROOKS, PETER;CHERESH, DAVID, A.;FRIEDLANDER, MARTIN |
分类号 |
A61K31/00;A61K31/12;A61K31/195;A61K31/198;A61K31/216;A61K31/42;A61K31/421;A61K38/00;A61K38/04;A61K38/12;A61K38/39;A61K45/00;A61P9/00;A61P19/00;A61P19/02;A61P27/00;A61P27/02;A61P29/00;A61P35/00;A61P35/04;C07C279/08;C07C311/06;C07C311/10;C07D263/24;C07K14/78;C07K16/28;(IPC1-7):A61K31/12;C07K5/00;C07K7/00;C07K16/00;C07K17/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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