| 摘要 |
Compounds of the present invention are represented by the formula (I). ( I ) wherein R1, R2, and R3 each is independently hydrogen, optionally substituted lower alkyl, or optionally substituted aryl; R4 is lower alkyl, aralkyl, aryl, or heteroaryl, each of which is optionally substituted; X is vinylene or ethylene; Y is or where R5 is hydrogen, lower alkyl, aryl, aralkyl, or a cation capable of forming a non-toxic pharmaceutically acceptable salt. The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the synthesis of cholesterol. They are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
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