发明名称 |
Process for steroidal peracyl glycosides |
摘要 |
PCT No. PCT/US93/02812 Sec. 371 Date Dec. 20, 1994 Sec. 102(e) Date Dec. 20, 1994 PCT Filed Apr. 2, 1993 PCT Pub. No. WO94/00479 PCT Pub. Date Jan. 6, 1994Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting alpha -cellobiosyl bromide heptaalkanoate and beta -tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl beta -O-cellobioside heptaalkanoate. The analogous preparations of hecogenin beta -O-cellobioside heptaalkanoate 11-ketotigogenin beta -O-cellobioside heptaalkanoate, and diosgenin beta -O-cellobioside heptaalkanoate are also disclosed. The process provides both high beta -anomeric selectivity and high yields.
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申请公布号 |
US5606041(A) |
申请公布日期 |
1997.02.25 |
申请号 |
US19940351472 |
申请日期 |
1994.12.20 |
申请人 |
PFIZER INC. |
发明人 |
BUSCH, FRANK R.;GOGGIN, KATHLEEN D.;LAMBERT, JOHN F.;SHINE, RUSSELL J.;WALINSKY, STANLEY W. |
分类号 |
A61K31/56;C07J17/00;C07J71/00;(IPC1-7):C07G3/00;C07H15/00;C07J9/00 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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