摘要 |
The present invention relates to compounds of the formula <IMAGE> I where X is a bond or -CH2-; R2 is pyrrolidino; R is OH, -OSO2-(CH2)n-CH3 or <IMAGE> R1 is hydrogen, OH, fluoro, chloro, -OSO2-(CH2)n-CH3 or <IMAGE> each R3 is independently C1-C6 alkyl, C3-C6 cycloalkyl, unsubstituted or substituted phenyl where the substituent is fluoro, chloro, C1-C3 alkyl or C1-C3 alkoxy; each n is independently 3, 4 or 5; and pharmaceutically acceptable salts and solvates thereof; provided that at least one of R and R1 is <IMAGE> The invention also relates to methods of use of the compounds of formula I and pharmaceutical compositions which comprise compounds of formula I.
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