发明名称 BICYCLIC AMIDINE DERIVATIVES USEFUL IN THERAPY
摘要 There are provided compounds of formula (I), wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro or cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents N(X) or CH(-(CH2)m-NXY); U represents NH, O or CH2; V represents (CH2)a; W represents (CH2)b; a, b, m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy.
申请公布号 WO9706158(A1) 申请公布日期 1997.02.20
申请号 WO1995GB01896 申请日期 1995.08.10
申请人 ASTRA AB;ASTRA PHARMACEUTICALS LIMITED 发明人 MACDONALD, JAMES, EDWIN;SHAKESPEARE, WILLIAM, CALVIN;MURRAY, ROBERT, JOHN;MATZ, JAMES, RUSSELL
分类号 C07D307/68;C07D333/38;C07D409/12 主分类号 C07D307/68
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