发明名称 |
BICYCLIC AMIDINE DERIVATIVES USEFUL IN THERAPY |
摘要 |
There are provided compounds of formula (I), wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro or cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents N(X) or CH(-(CH2)m-NXY); U represents NH, O or CH2; V represents (CH2)a; W represents (CH2)b; a, b, m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy. |
申请公布号 |
WO9706158(A1) |
申请公布日期 |
1997.02.20 |
申请号 |
WO1995GB01896 |
申请日期 |
1995.08.10 |
申请人 |
ASTRA AB;ASTRA PHARMACEUTICALS LIMITED |
发明人 |
MACDONALD, JAMES, EDWIN;SHAKESPEARE, WILLIAM, CALVIN;MURRAY, ROBERT, JOHN;MATZ, JAMES, RUSSELL |
分类号 |
C07D307/68;C07D333/38;C07D409/12 |
主分类号 |
C07D307/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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