SYNTHETIC OLIGONUCLEOTIDES WITH ENHANCED RIBONUCLEASE ACTIVITY

摘要

Disclosed are catalytic synthetic oligonucleotides having enhanced ability to site-specifically endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. These synthetic catalytic oligonucleotides include at least one 5-propynyl substituted pyrimidine nucleotide at a flanking region. Also disclosed are methods of preparing and utilizing the synthetic catalytic oligonucleotides of the invention, and pharmaceutical formulations and kits containing such synthetic catalytic oligonucleotides.