发明名称 |
PREPARATION OF TRIAZOLES BY ORGANOMETALLIC ADDITION TO KETONES AND INTERMEDIATES THEREFOR |
摘要 |
The invention provides a process for the preparation of a compound of formula (I), or an acid addition or base salt thereof, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and trifluoromethyl; R<1> is C1-C6 alkyl; and "Het" is pyrimidinyl optionally substituted by 1 to 3 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, oxo, benzyl and benzyloxy, comprising reaction of a compound of formula (II), wherein R is as previously defined for a compound of formula (I), with a compound of formula (III), wherein R<1> and "Het" are as previously defined for a compound of the formula (I) and X is chloro, bromo or iodo, in the presence of zinc, iodine and/or a Lewis acid and an aprotic organic solvent: said process being optionally followed by conversion of the compound of the formula (I) to an acid addition or base salt thereof.
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申请公布号 |
WO9706160(A1) |
申请公布日期 |
1997.02.20 |
申请号 |
WO1996EP03376 |
申请日期 |
1996.07.26 |
申请人 |
PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A.;PFIZER LIMITED;PFIZER INC.;BUTTERS, MICHAEL;HARRISON, JULIE, ANN;PETTMAN, ALAN, JOHN |
发明人 |
BUTTERS, MICHAEL;HARRISON, JULIE, ANN;PETTMAN, ALAN, JOHN |
分类号 |
C07D239/26;A61K31/4196;A61K31/505;A61P31/04;C07D;C07D239/30;C07D239/34;C07D239/36;C07D249/08;C07D403/06;(IPC1-7):C07D403/06;A61K31/41 |
主分类号 |
C07D239/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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