METHOD FOR NON-INVASIVE BLOOD ANALYTE MEASUREMENT WITH IMPROVED OPTICAL INTERFACE

摘要

This invention is a method for non-invasive measuring of the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques in conjunction with an improved optical interface between a sensor probe (11) and a skin surface (12) or tissue surface of the body containing the blood to be analyzed. An index matching medium (22) is disclosed to improve the interface between the sensor probe (11) and the skin surface (12) during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial square analysis relative to a model incorporating analysis of plural known blood samples.