Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
申请公布号
DE69307305(D1)
申请公布日期
1997.02.20
申请号
DE1993607305
申请日期
1993.04.16
申请人
MCMASTER UNIVERSITY, HAMILTON, ONTARIO, CA;ZYMOGENETICS, INC., SEATTLE, WASH., US
发明人
RUBENS, FRASER, D., BURLINGTON, ONTARIO L7P 4R4, CA;BISHOP, PAUL, DOUGLAS, FALL CITY, WA 98024, US