Resolution of 1-azabicyclo{2.2.2}octan-3-amine, 2-(diphenylmethyl)-n-{{2-methoxy-5-(1-methylethyl)phenyl}methyl}

摘要

PCT No. PCT/IB96/00648 Sec. 371 Date Dec. 16, 1997 Sec. 102(e) Date Dec. 16, 1997 PCT Filed Jul. 4, 1996 PCT Pub. No. WO97/03984 PCT Pub. Date Feb. 6, 1997A process for resolving 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] in which 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] is reacted with 1R-(-)-10-camphorsulfonic acid in a solvent capable of dissolving both the foregoing reactants and selectively dissolving the camphorsulfonic acid salt of the corresponding (2R, 3R) enantiomer relative to the (2S, 3S) enantiomer.