ANTIDEPRESSANT 1-ARYLALKYL-4-(ALKOXYPYRIDINYL)-OR 4-(ALKOXYPYRIMIDINYL) PIPERAZINE DERIVATIVES

摘要

Novel compound of formula I and pharmaceutically acceptable salts thereof are useful CNS agents: <IMG> (I) wherein X is CH or N; X' is CH or a direct covalent link; Y is CH, CH2 or N; Y' is N, NH, O or S; R1 is H, Br, Cl, F, C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxycarbonyl, CN, CONH2 or CH3SO2NH; n is 2 or 3; R2 is H or C1-4 alkyl; R3 is C1-4 alkoxy; R4 is H, Br, Cl, or F; and Z is CH or N.